Isotopically Labeled Compounds
Medchemexpress LLC Neo Spiramycin I-d3 | 70253-62-2 | C36H59D3N2O11 | 500 UG
Neo Spiramycin I-d3 is the deuterium-labeled form of Neo Spiramycin I, an active metabolite of Spiramycin that exhibits antimicrobial activity. It is widely used in veterinary medicine.
- Can be used as a tracer.
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes are integrated into drug molecules as tracers for quantitation during drug development.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Trametinib-d4 | 871700-17-3 | 99.87% | 619.42 | 1 MG
This product is a stable isotope-labeled compound, specifically a deuterium-labeled version of a MEK inhibitor. It is an orally active inhibitor that targets MEK1 and MEK2, demonstrating activity at very low concentrations. The compound is noted for its ability to activate autophagy and induce apoptosis. It is intended for research use only and not for human therapeutic applications.
- Features
- Deuterium labeled compound.
- Targets MEK1 and MEK2 with high potency.
- Activates autophagy.
- Induces apoptosis.
- Oral activity.
- Benefits
- Can be used as a tracer in research.
- Serves as an internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS.
- Deuterium substitution may influence pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC 2,2'-bipyridine-d8 | 32190-42-4 | 99.3% | 164.24 g/mol | C10D8N2 | 1 MG
2,2′-Bipyridine-d8 is the deuterium-labeled isotopologue of 2,2′-bipyridine designed for use as a tracer or internal standard in quantitative analytical techniques such as NMR, GC-MS, and LC-MS. Sold for research use only, it is supplied in small-quantity formats for analytical and method development applications.
- Deuterium-labeled isotopologue suitable as tracer or internal standard.
- High purity (99.3%).
- Molecular formula C10D8N2; molecular weight 164.24 g/mol.
- Available in small quantities (1 mg) for analytical use.
- Documentation available: data sheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC Clozapine-d8 | 1040850-25-1 | MFCD00223707 | >98% | C18H11D8ClN4 | 1 MG
Clozapine-d8 is a deuterium-labeled clozapine. It is an antipsychotic used for the research of schizophrenia, exhibiting high affinity for various neuroreceptors.
- Antipsychotic used for schizophrenia research.
- High affinity for several neuroreceptors.
- Potent antagonist of dopamine D2.
- Inhibits muscarinic M1 receptor and serotonin 5HT2A receptor.
- Potent and selective agonist at muscarinic M4 receptor.
Cayman Chemical cis-10-hydroxy Nortriptyline
An active metabolite of amitriptyline and nortriptyline; formed from amitriptyline and nortriptyline by CYP2D6; inhibits norepinephrine reuptake in rat cortical slices (EC50 = 160 nM)
Medchemexpress LLC Monomethyl auristatin E-d8 | 2070009-72-0 | MFCD28386277 | 99.3% | 726.03 | C39H59D8N5O7 | 10 MG
MMAE-d8 is a deuterated isotopologue of monomethyl auristatin E, a potent mitotic inhibitor that disrupts microtubule dynamics. The deuterium-labeled compound is designed for use as an analytical standard, tracer, or internal standard in antibody-drug conjugate research, mass spectrometry, and pharmacokinetic studies. Supplied as a high-purity solid for laboratory use.
- Deuterated isotopologue for analytical and tracer applications.
- Potent tubulin inhibitor useful as an ADC payload reference.
- High reported purity suitable for sensitive assays.
- Available in small milligram pack sizes for research workflows.
- Supplied as a stable solid for accurate dosing and handling.
Medchemexpress LLC Creatinine-13C | 1173022-95-1 | >99.9% | 5 MG
Creatinine-13C is the 13C-labeled Creatinine, a breakdown product of creatine phosphate in muscle that is usually produced at a fairly constant rate by the body. This product is intended for research use only and serves as a valuable tool in various analytical and research applications due to its stable heavy isotope label. It is particularly useful for precise quantitative analysis in studies involving pharmacokinetics and metabolic profiling.
- Used as a tracer in research studies.
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of carbon for drug development processes.
- Can influence pharmacokinetic and metabolic profiles of drugs.
- Molecular formula is C313CH7N3O.
Medchemexpress LLC Diphenhydramine-d6 hydrochloride | 1189986-72-8 | 99.3% | 5 MG
Diphenhydramine-d6 hydrochloride is the deuterium-labeled form of Diphenphenhydramine hydrochloride, a first-generation histamine H1-receptor antagonist with anti-cholinergic effects. It can cross the ovine blood-brain barrier (BBB). Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules primarily as tracers for quantitation during drug development. Deuteration, specifically, has gained attention for its potential to impact the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Nizatidine-d3 | 1246833-99-7 | 98.8% | 1 MG
Nizatidine-d3 is the deuterium labeled Nizatidine. Nizatidine is a potent and orally active histamine H2 receptor antagonist, used for the research of stomach and intestines ulcers. It decreases the secretion of gastric acid the stomach makes and prevents ulcers from coming back after they have healed in animal models.
- Potent and orally active histamine H2 receptor antagonist
- Used for research of stomach and intestines ulcers
- Decreases secretion of gastric acid
- Prevents ulcers from returning after healing
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Targets the H2 receptor
Medchemexpress LLC Mebeverine acid-d5, hydrochloride | 475203-77-1 | 99.0% | 1 MG
Mebeverine acid-d5 hydrochloride is a deuterium labeled form of Mebeverine acid hydrochloride, a secondary metabolite of the intestinal antispasmodic agent Mebeverine. It is formed by the body's hydrolysis of Mebeverine, acting as a key circulating metabolite and an important marker for oral Mebeverine. This compound is intended for research use only, leveraging stable heavy isotopes for quantitation in drug development.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Cambridge Isotope Laboratories Chloroform-D(D,99.8%), .03% V/V Tms, 865-49-6, Mfcd00000827, 100 G
Chloroform-D(D,99.8%), .03% V/V Tms, 865-49-6, Mfcd00000827, 100 G
Medchemexpress LLC 1,2-dibromoethane-d4 | 22581-63-1 | MFCD00037499 | >98.0% | 191.89 g·mol⁻¹ | C2Br2D4 | 100 MG
1,2-dibromoethane-d4 is the deuterium-labeled analogue of ethylene dibromide supplied as a neat liquid for use as an isotopic reagent, internal standard, or NMR solvent in research and synthetic applications. The product has formula C2Br2D4, CAS 22581-63-1, and a molecular weight of approximately 191.89 g·mol⁻¹. It is provided with high isotopic enrichment and chemical purity for analytical reliability. For research use only, not for human consumption.
- Deuterium-labeled (d4) for isotopic tracing and NMR applications.
- High isotopic enrichment suitable for quantitative analysis.
- Chemical purity typically >98.0% to ensure analytical reliability.
- Useful as an internal standard and reagent in synthesis and spectroscopy.
- Liquid form with formula C2Br2D4 and molecular weight 191.89 g·mol⁻¹.
- Store cold (refrigerated or -20°C recommended) to preserve stability.
Medchemexpress LLC 1,2-distearoyl-d70-sn-glycero-3-phosphocholine | 56952-01-3 | MFCD00674391 | 99.0% | 860.577 | C44H18D70NO8P | 5 MG
DSPC-d70 is the deuterium-labeled form of 1,2-distearoyl-sn-glycero-3-phosphocholine used as an analytical tracer and as a lipid component in liposome and lipid nanoparticle formulations.
- Perdeuterated phosphatidylcholine (d70).
- Used as a tracer or internal standard for NMR, GC-MS, and LC-MS.
- Suitable for liposome and lipid nanoparticle formulation.
- Purity 99.0%.
- CAS number 56952-01-3.
- Molecular weight 860.577.
- Packaged as 5 MG.
Medchemexpress LLC Menaquinone-4-d7 | 1233937-25-1 | 250 UG
Menaquinone-4-d7 (Vitamin K2(MK-4)-d7) is the deuterium labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also an adjunctive therapy for the pain of osteoporosis.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules.
- Used as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Veratrole-d2 | 203645-56-1 | 99.7% | 25 MG
Veratrole-d2 is a deuterium-labeled form of Veratrole (1,2-Dimethoxybenzene), a compound naturally found in plants. It plays a significant role in plant reproduction, species differentiation, and interactions with pollinators due to its circadian rhythm of release. Deuterium-labeled compounds like Veratrole-d2 are valuable in drug development as tracers for quantitation and for their potential to alter pharmacokinetic and metabolic profiles.
- Deuterium labeled compound
- Molecular formula C8H8D2O2
- Molecular weight 140.18
- High purity 99.7% (GC)
- Isotopic enrichment 98.5%
- Appearance is a colorless to light yellow liquid
- Targets isotope-labeled compounds and cytochrome P450
- Can be used as tracers for quantitation
- Has potential to affect pharmacokinetic and metabolic profiles